dead space crashes on launch

Dead Space 1 - installed through Origin - now crashes on launch. I've researched this problem here and taken applicable steps, but my story seems to differ from the other threads in that A) my copy of Dead Space was installed through Origin, and B) upon the very first install, I was able to launch the program and make various configuration changes (most notably, to the resolution / refresh rate of the game, which are bizarrely linked) before exiting it. Since then, however, it crashes.

I've tried steps in other threads including reinstalling Microsoft components, restarting the PC itself in a limited boot mode via msconfig, and uninstalling and reinstalling Dead Space itself. Since no relevant changes have occurred on this computer from the first time Dead Space launched and the first time it crashed on launch, I think that - like many other programs - it leaves behind some configuration files, even after its uninstallation, that may be causing the problem.

I'd like to know, first, what residue is left behind after an uninstallation of Dead Space, so that I can manually delete said residue after uninstalling the program. I think that if I can do a clean - TRULY clean - wipe of the program after uninstalling it, I may be able to get it to run, like it did on the very first install.

Note also that I'm using a monitor with a resolution of 2560 x 1140, and refresh rates of 60, 120, and 144 Hz. Dead Space provides separate listings for every resolution and refresh rate combination. It took me approximately one minute to advance the setting to 2560 x 1140 @ 144 Hz. I think it may be more comfortable running at 60 Hz.

At any rate, any assistance would be appreciated. Thanks for your time.