Blue border for selecting/activating doors/objects is non-functional or intermittently flashing

Windows Vista 64-bit.  Dragon Age: Origins Ultimate Edition, Mass Effect, and Mass Effect 3 all work fine.  But with Mass Effect 2 the blue border on terminals, doors, mini-games... and the text prompt describing the selectable object and the action to be performed that appear at the top middle of the screen are not appearing.  Origin Help advised a uninstall, re-install, and this will now be my fourth time doing this.

For the initial installation and game play, the blue border would not appear at all, and I could only find it when looking up or down and passing camera orientation over the object.  That gave me a flash of the blue border, so I now knew what to look for.  But it's certainly not appearing like it should.  I can have my character stand right in front of the object and still nothing, when there should be a text box showing up when the character is facing the object even from across a room.  I finally discovered I could sometimes select the object if I rapidly pressed the space bar (initially redirected this command to the E key since I'd been playing Mass Effect for so long, but then changed it back to the space bar hoping it would help) while moving from the menu back into game play when the border would flash briefly.  As well, the mouse movements were hypersensitive and the smallest movement would overshoot targets to the point that by the time I could actually get properly aimed, the target had moved directly in front of my character.  I finally contacted Origin Help since I didn't want to do this for the entire game.

After the first re-install, the game seemed to work fine with static blue borders and texts appearing as they normally should, but when I changed graphics settings to window (no border), re-sized the screen, and set all settings to No, the problem was back.

At the next re-install, I did not change any settings.  The blue border flashes intermittently, text/action box doesn't appear as much as the border seems to, but I could be wrong about that as I'm not looking up there as much as I'm trying to catch the border when it appears.  Again, the only sure way of selecting the object is a rapid jabbing of the space bar until they are activated at the same time.  At least I don't have to exit to the menu and re-enter game play to do it now.

Today Origin Help advised that I go to the Mass Effect 2 shortcut on desktop > Properties > Compatibility > check box for Run This Program In Compatibility Mode For: Windows XP (Service Pack 2).  Then launch the game, and the problem is still there.  So Origin Help sent me here.

Kind of confused about that, but here I am. 

If anyone is kind enough to respond, please understand that I'm an expert in other things, but not computers.  I don't speak computer, so it takes me a long time to translate things like HUD into Heads Up Display and so forth.  I've spent hours today trying to understand how to enable ME2 cheat codes/console, as it seems no one bothered to write in tiny, non-computer lingo, regular English words for those of us who aren't computer whisperers.  What I'm saying is if anyone has a suggestion as to what I need to do to fix this problem, or needs more information from me, it would help me a lot if you explained how to do what I need to do clearly and simply, without the normal abbreviations and implied knowledge that most people probably have.  I can search the web to learn things, so I'm not entirely dim, but if you tell me to grab this file or tell you that detail, I'll need to know where to look usually, and I'll need a step by step, hold my hand type of guide.  You'd be surprised what I can misinterpret!

Thanks to anyone who can help.  It would be nice to feel I haven't wasted my time and money on a game I'll never be able to play.  Much Peace.