Suddenly can't resume/start a new game in Mass Effect 2

@Kavadohr

Try to run Origin and the "MassEffect2.exe" as Administrator.

Do you use any Mods?

Did you edited one of the games Ini files?

If that don't helps, create a DxDiag in text file format and post it with your next reply. You can do that  with the "choose file" button at the bottom right corner of the reply window. 

Thanks for the advice!

I'm afraid running both Origin and the MassEffect2.exe as admin doesn't change anything.
I used the "Mass Effect Updated/Improved Textures Mod" for my second Shep in ME1, I can't recall changing any ini files though..
Got the DxDiag ready for you.

@Kavadohr

There are several "Update;taskhostw" errors in your DxDiag, do you get a error message at system start?

Run the Windows System File Checker Sfc /scannnow and post the concluding message.

Furthermore, your Win 10 is at build 14393. The Creators Update should have been installed by now, I assume that this is because of the above error, or did you blocked the update manually? 

Wenn du das Lieber in Deutsch besprechen willst kann ich den Thread ins Deutsch Forum verschieben.

I've encountered no error messages so far. Though I must confess I'm not all that educated when it comes to this kind of stuff..so if there's nothing obviously wrong I probably won't notice it.
Also, I can't say I know anything about a Creators Update. I don't usually block updates.
The System File Checker didn't find any "Integritätsverletzungen", if that helps you in any way..

Das kannst du gerne machen, danke. Dachte dass ich ggf. im englischsprachigen Bereich mehr erreiche.

@Kavadohr

Then I will leave it here if you don't mind.

OK, lets get your system up to date first.

Go here, the website should tell you: "Wir haben festgestellt, dass Sie Windows 10 nutzen. Wenn Sie auf die neueste Version aktualisieren möchten, klicken Sie auf Jetzt aktualisieren"

Just do that.

(Note: As usual you should back up your important data before you preform a major update.

Updated Windows, everything went smoothly as far as I can tell. Mass Effect is still acting up for now though.

Thanks for your time so far!

@Kavadohr

No Problem. 🙂

Please create a new DxDiag and post it like before.

Also try to repair the game again.

Sorry for the slow response!

Repairing the game didn't change anything I'm afraid, got the new DxDiag ready for you though.

Thanks again! 

@Kavadohr

No problem.

Disable the Origin cloud sync feature.

Close Origin and the game.

Move the "Mass Effect 2" folder from your ">drive<:\Dokumente\BioWare" folder to your desktop > Start Origin > Start the game. (Make sure you still run Origin as Administrator)

If that don't helps, crate a second Windows user account > reboot > logon to the new account and test the game there.

If that still don't helps, is the game installed to your C: or to your D: drive? Either way, deinstall the game from the Windows control panel and try a installation to the other drive. 

You can change the Origin installation directory in this way: In Origin, menu top left corner > Origin > Application settings > Installs & Saves > On your computer > Game library location. (Origin Menü > Anwendungseinstellungen > Installation und Spielstände > Auf deinem Computer > Ort der Spielebibliothek)

Andere Installierte Spiele sind nicht von der Veränderung betroffen und werden weiter funktionieren.

Sorry for taking way too long to respond!
So far, I've tried everything except installing the game to another drive. Will be doing that as soon as possible, just wanted to let you know that I haven't dropped this issue yet.

Thanks for your patience!