We fixed the weirdness with trying to add points while drinking the Draught of Reconfiguration. Now you should be able to add points just fine and your options won’t be greyed out.
Fixed in Patch 1.52.100
I also have this problem, and it's making the game a lot less fun for me.
I have a vampire who I royally, socially messed up, she burst into tears and hissed, I had another that I made a guilty drinker, who was also sloppy, I decided I disliked these traits so I made the reconfiguration potion to reset the skills. When I did I could only get them to level 1 or 2, of the 3 levels, before they greyed out, despite having the points. I learned to reload my game when this happened.
But now, my vampire is a 5 star celeb, she spends a lot of time in clubs, and she's the friendly type, a good celeb, when she starts to talk to someone she randomly hisses and every sim in the vicinity suddenly loses a lot of friendship with her. And the sloppy drinker, who was also guilty before the reset? Well he's costing a fortune in plasma packs as he gains a stupidly low amount of plasma from each pack. I've read back through the threads people have posted and all I can gather is that this is a huge bug that hasn't been fixed for months. I've only recently bought the game and I'm a little peeved by this.
Most of the work arounds only work for a short while, which isn't ideal.
