@alanmichael1I've noticed it happens quite often for me. If they're "Enraged", I'll always have the "Apply mite treatment" option. That gets them down to "irritated". I then "Bond" and they go calm.
However sometimes they'll be irritated and I won't have the option to apply treatment. I try to "Bond" but it doesn't get them Calm. If I just leave it like that, they'll be forever "Irritated". So, those times I just shift-click, and select "Turn on mites". Then a normal click will show the treatment. I select that and they're calm again.
I see it as a bug in the game. If I encounter bugs like that, I have absolutely no problem using cheats to correct the situation.
