I don't feel good about the idea of having mental issues in my game simply because I don't think TS4 can pull it off properly.
Let's say they actually add depression into the game - Everyone experiences it differently. And I can only imagine they would give depressed Sims a constant sad moodlet or let them gain fitness slower and these things don't happen for everyone who suffers from depression. I really don't think they can do it justice.
On the other hand I do like the idea of physical disabilities, like needing glasses, a wheelchair, only having one arm or leg etc. I think it's easier to pull that off because it's all "just" based on animations. (I'm not sure how much I want emotions involved with it.)
I would like to see lifts for wheelchairs on stairs, eye tests and the need for glasses (or contact lenses if you don't want your Sim to wear glasses), crutches, bionic arms and legs, guide dogs for blind/visually impaired people etc.
I never really thought much about disabilities in Sims games so these are only my immediate thoughts.
