Not consciously. I made a teen sim some months back and spent hours on his face. When I was finally done, I realized he reminded me of my very first BF back in my HS days. I didn't set out to make him that way, it's just who he resembled or reminded me of when I finished working on his face. I ended up giving him the same first name, but with a different spelling.
Apart from my self sim, I've never purposely made somebody to look like anybody I know in RL, but I do base some of them off characteristics and personalities of people I've met over the years.