Game starts up and while playing the message not responding pops up

@mamapanda

Did you remove all your mods/cc completely?
For example, move the mods folder from C:\Users\Username\Documents\Electronic Arts\The Sims 4 to your Desktop and start the game.

Otherwise, please post a DxDiag:
https://help.ea.com/en-us/help/pc/how-to-gather-dxdiag-information/

You can also reset your files to factory settings.

• Make a backup; copy your The Sims 4-folder from C:\Users\Username\Documents\Electronic Arts to an external drive or somewhere else on your computer, for example your desktop.
• Rename the The Sims 4-folder in C:\Users\Username\Documents\Electronic Arts to The Sims 4_backup
• Start the game, make a new save, and see if the error is gone. 
  (The game will have created a new The Sims 4-folder in your documents, this is supposed to happen)
  
  
  • If yes, continue
  • If no, post a reply telling us the error is still there
• Start putting folders back in the new The Sims 4-folder. Observe! After every file/folder, start the game and make sure it still works, before putting in the next one.
  • Options.ini - your game settings
  • Saves - your old saves. The sub-folders are not needed. If putting these back causes problem, try putting one back at a time.
  • Screenshots
  • Custom music - if you have any
  • Tray - your library objects; like lots, rooms and sims
  • Mods - your mods and cc, might cause problems when putting back

If putting back one of the folders was problematic and you did not work it out, please post a reply and we'll see if we can find what your problem is!

Source: https://help.ea.com/en-us/help/the-sims/the-sims-4/backing-up-and-resetting-the-sims-4/

Good Luck! 🙂