I'm really surprised this got no attention at all over much more minor issues because it's a huge problem that eventually hoses your save for good and causes it to crash frequently when you save or change lots.
The root seems to be an insane amount of buffs that suddenly get stuff into the save.
Here is the point where it happened to me with before and after save files:
10.8 MB save 10/13/14 1:57PM
https://onedrive.live.com/redir?resid=DC056E1DEE3FD697%213844
Count of the word "buff" in this save is 26 times.
34.0 MB save 10/13/14 3:37PM
https://onedrive.live.com/redir?resid=DC056E1DEE3FD697!3845&authkey=!AJ_dQi9PVydZTW8&ithint=file%2csave
Count of the word "buff" in this save is 563,202 times.
That's just an hour and a half later. There's no way it should be doing that.
And the file just continues to bloat. It ended up being about 56MB when the game got to the point where it crashed on saving so frequently that I just gave up and started over. One user at the official forums has a save file of over 100MB.
Someone really needs to look into this. I linked my save files above with before and after saves which as you can see were made in a short time span.