Re: Mass Effect 1 (Legendary Edition) lagging after 1 hour of Playtime

I have the same problem and it's even worse!

AMD Ryzen 9 5900X

Geforce RTX 3080

DDR 32 GB Ram

M2 SSD

I've deactivated every Overlay (Steam, Nvidia, Origin) but I'm still most of the time at 50-80 fps. If I would use my wireless mouse (Roccat Leadr) in wireless mode, it's even worse at 25-40 fps. So I've to plug in the cable for my Mouse to get at least 50-80 fps

After playing 1-2 hours the same happens to me and the fps drops to 1-5, I'm not able to do anything in the game anymore and have to quit with ALT + F4! The funny thing is, my mouse and desktop continue to stutter until I plug it out and in again. Can it be that you also use a wireless mouse? Maybe there are some problems with specific peripherals? 

I'm playing other games (Metro Exodus, Battlefield V, Cyberpunk 2077) on 3840 x 1600 resolution in Max Details with full raytracing and never had any problem. There is definitely some poor coding or interference with something!