Crowd noise also, make the routes go fuzzy or just have a really random and odd snap of the ball if the crowd noise is so loud, obviously it's a 1 in a 1,000 play, but that element of randomness makes football. I personally prefer playing on the road, as the opposing crowd noise and hostile environment is fun to play in, but I'd love to have that really emphasized. Going to Seattle, Pittsburgh, Foxborough, intimidating, but it creates an atmosphere.
Wear and tear also, maybe when a running back is 20-27, playing a full season at a high volume of carries does not deteriorate the proposed wear and tear bar, but as the player gets older or carries are exceptionally high, this decreases and so does the overall. Same with a 39 year old Quarterback, why continue to play him in a blow out? Sure you can avoid injury, but you also want him fresh (a small reason why Tom Brady has lasted so long and Peyton hasn't, Peyton refused to be benched, as an All-time great that's understandable - he commands that respect, but ultimately it may have cost him another year or so). The same with the end of the season, why should we rest our starters? They either get injured or not, that's not a real incentive. However if they're worn down, tired, that rest is required.
Also, fatigue isn't really a factor in Madden, it doesn't seem possible to tire a defense out, make them "gassed", introducing that would make Madden an even better experience