@redinationdane
Please try these steps below. If they do not work, create a new thread and label the title "Cannot launch Madden NFL 21 on Xbox One S" so we can keep PC and Xbox troubleshooting separated.
How to power cycle your Xbox console:
- Turn off the Xbox One console by pressing the Xbox button on the front of the console for about 10 seconds until it shuts down completely.
- Unplug the console’s power cable. Wait 10 seconds.
Important Be sure to wait 10 seconds. This step resets the power supply.
- Plug the console power cable back in.
- Press the Xbox button on your console to turn on the Xbox One.