@Insta_Buzz Screen plays do work. While I don't run them much, I have had a few go for big gains against me because of the defense I was running (makes a big difference).
If the edge rushers are in contain (which is POPULAR when people blitz this year), they will abandon the pass rush and run with the back after the screen blockers leak out. The defender will be in good position to make a play, because he will be between the blockers and the back.
Against a zone defense, you will be able to get the most yards, as long at there are no contain assignments on the field.
Man coverage will usually beat a screen unless the man defender on the back is on the wrong side of the field.
Hope this helps.
Later