Try to repair the game. (in Origin > Game Library > right click ME3 > Repair)
Huh, no, that doesn't work.
Never heard of this before.
Any mods?
What @ThandalNLyman said.
Plus what do you mean by "That doesn't work"? Is the Repair function not working or did it make no difference?
Make sure Origin and the game are closed.
Then move the "BIOGame" folder and the "Profile" folder from your "Documents\BioWare\Mass Effect 2" folder to your desktop. > test.
• No mods, since I re-installed this game I have yet to start a campaign game.
• Repairing is the first thing I tried, it checked and stuff, but that didn't help.
If you go ingame and try to change your key bindings, does it activate as waiting to input and doesn't accept anything??
Cause it kinda sounds like the game is looking at a different keyboard as the default keyboard instead of the one you want. Something to check is look into your connected items and see if it lists an alternate keyboard or input device and remove it, also unplug any additional controllers or touchpads, etc....
