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I had the same issues. And the issues somehow comes from EA App itself. It cannot launch the game without it freezing. However if you launch the game completely circumventing the EA App the problems don't occur.
This can be done by using Steam to launch the game for you.
When you are in steam, go to your library, at the bottom choose "Add a game" and pick "Add a non-Steam game".
If Mass Effect appears on the list, just pick it. If it doesn't, select "Browse..."
Mass Effect is by default installed at "C:\Program Files\EA Games\Mass Effect\Binaries" and select "MassEffect.exe"
Then select "Add selected programs", once this is done, launch the game from Steam.
After doing this the game ran fine for me. It is possible you can also run it from the installation folder it self. Same folder as above, and run "MassEffect.exe".
EA App is shockingly bad. It has to rely on a direct competitor's product to run its own products properly.
I sincerely hope that this helps you, as it helped me.
Sadly as long as they have your money they do NOT care about anything else . Even on competitors platforms they're games will not run because they require everything run through the terrible ea app that they will never update (unless the update is EVEN worse then current )