On the Steam platform I had to disable dynamic shadows and light shadows and I also had to play in window mode just to be able to do the quests on Illium.
lowering the sound settings to 16bit, 44.1KHz actually solved the issue for me. Thanks!
Coming in in June of 2020 to say thank you--this worked for me as well on Windows 10. Go into Settings/Sound, click your sound device, Properties, Advanced tab and set to 16 bit/44.1KHz. I also set the game to run Windowed Borderless and turned off the shadows/lighting/HQ Bloom options.
I also had the Katsui DLC problem where you finish the mission then when you exit the recap screen the cut scene that plays when you're boarding the Normandy crashes your game. I tried every "-nomoviestartup" fix out there, etc. etc. etc. but nothing worked, ended up using the Gibbed Save Editor and moving my location to the Normandy manually. It worked, but I'll need to also adjust the right flag to mark the mission complete in the save editor too. Sure, you load on the bridge in a party dress and heels, but that's fixable. 😉 I used the following player position in the save file if it helps anyone:
Base Level Name BioP_Nor
X -2.23265076 3388.90527
Y 3388.90527
Z -130.150009
Should load you right at the map in CIC.
