Just for anyone in the future having a similar issue. I had a problem launching the game after applying a few mods. I disabled mods one by one then eventually reinstalled the game and was considering doing a fresh windows install. As a last resort, I realised I edited some nVidia setting via nVidia Inspector. Reverting these changed back to default and then applying one by one resolved my issue and I am fairly sure all it was was a mistype for one of the codes as it is completely fine now.
The exact scenario I had in case you are troubleshooting. Once I launched the game I would get the Bioware intro and the first loading screen then once the menu kicked in I got Black Screen and heard music skipping through a sequence like very poor buffering. The game would crash about 10s Later.
Hope this helps someone.