Hi
I got the directx problem too. 5-10 seconds after cutscenes or loadscreens it crashes immediately when ever I try a graphic setting higher than lowest.
Had the same issue with The Witcher 3 about 2 years ago after I updated from win 8 to win 10. Some weeks later it worked again without me trying to fix it. (Or I gave up)
My System:
I7 4 core
8 or 16GB Ram
gtx 780 Ti
SSD HD
Only Intel standard overclock. I am not able to do such settings so its standard.
What I tried so far:
Install directx from game folder.
Instal vc++ from game folder
Install newest Nvidia driver
Trying different graphic settings. Only low works. Its terrible lol.
Updating Main Board Drivers and stuff didn't work for The Witcher 3 in 2015 so I think I don't even try this here.
All other Games work with no Problems so I think it must be a Mass Effect Problem...
It is so frustrating that my Favorit Games seem to have those issues while cheaper Games just work.
I mean I don't even have some special Hardware. I think I really have very common Gamer Stuff with standard Settings and Drivers.
Best regards.