@holger1405
My game finally works! So after reinstalling Origins and ME3, I tried turning off compatibility mode to see if that would work. It did not, caused same issues (Steam refreshing, Origin opening and closing), and still the game wouldn't launch, However, I searched for the MassEffect3.exe app under the Binaries folder, ran that as admin, and the game actually launched! Since I didn't have both Mass Effect 1 and 2 reinstalled, I knew I would have to start a new game. Strangely enough, I found my 2 characters Save Files that carried from ME2 (Male, which I finished already and Female, which I didn't.) I did notice however that I was getting achievements (again) as if I never got them to begin with, but Steam obviously has everything I collected from the first gameplay through. I managed to play the game through the first 2 priority missions, up to the point to check if ALL the DLC was installed correctly, and so far they are (clothing, weapons, mission for Prothean squadmate). I am hoping this is a permanent fix, seeing as I actually got the game to work, I just can't launch from Steam or from Origin, even though the .exe launcher is from the steamapps folder. Anyway I just wanted to say thank you so much for your technical advice and suggestions, and of course, patience. I know this game is pretty old, but I have enjoyed this series since I first touched it on PC. I am also appreciative of you taking the time to help me and others find solutions for this.