@1ago wrote:
Do you by any chance use two monitors and an extended desktop? I've had this on occasion that my mouse cursor would skip to the other screen, especially in hectic situations where I would move very fast and to the edge of the screen. Somehow the cursor then would appear on the 2nd screen, even if only for a millisecond and thus trigger ME3 to become minimized - although I played in Fullscreen. Very annoying but I haven't found a fix apart from unplugging the 2nd monitor while playing.
1ago may be on to something, however, I have two monitors as an extended desktop and have not run into this issue.
I run Mass Effect in full screen mode and have yet to get the mouse to leave the Primary Monitor while it is running. I have used alt + tab to get my mouse to the other screen to change the web browser page, or whatever handy notes I left on the other monitor.
I can assure you there have been many frantic scrolling, zooming, running around and the mouse has not rolled over to the other screen in Mass Effect 3.
Star Wars the Old Republic on the other hand, does allow the mouse to go over there and once I click on the browser, SWTOR then minimizes.