I have a full biotic play going for the second round...ie, I did a normal or maybe it was hardcore play, then amped it up this time around to Insanity level. She is about level 71 now, finished the game at low 60s in level. I had points maxed in all Biotics and I mean ALL, plus some in tech, and Combat. The tech was mostly passives and combat was guns and passives. The reason was simple, tech passives give more shields, and bonuses to companions, and Combat makes my guns better and gives health. I never switched out to tech or combat profiles, always kept just pure Biotic. Honestly, if you use guns, then by all means put some points into them for effectiveness and weight control.
As far as Nova, Charge and Annihilation, well, if you like that kind of play they can be fun, if not, then as the points come around, still put them in for the bonuses you will get from more points in Biotics, and just don't use them.
For a fun and different play, a charge, cloak and your favorite third power can be really fun....charging in, cloaking and then blasting away can be very effective....but not to everyone's liking.
Cloak then charge. For the Vanguard surprise achievement.
