With any upgrade that seems to be really expensive, you have to realize, they aren't intended for you to have until further in the game. But the nanotech only utilizes any placement on the map without upsetting the Sims, because there's no pollution. Which in the later parts of the game, space is a huge deal. you'll be able to place anywhere. Regardless, I'm going to have factories, garbage, and sewage on the very edge of my map and government right where it should be....next to huge piles of crud. 😂 So don't worry about them until way late in the game when you will be making tons of money off tax revenue and high priced item sales.