i'll be nuking one of my towns when the next land release comes out
main advice is have an idea of what you want
i.e the parts of your town you are happy with at the moment take screenshots so you can replicate it
also once nuked get all buildings/decos from a certain group out of storage and put them together at the bottom of your screen. for example if you want to make a Town Dump area then take out any recycling depots/trash/bins/trucks/etc from storage and put then next to each other. that way when you do get around to making that particular bit you know all the items you need to include in your design