I've got a weird glitch in King-Size Homer's questline, at the 6 hr. "Let it All Hang Out at the Beach" phase. It seems like his task is canceled when I click the check mark on a completed Kwik-E-Mart -- not sure if it happens when any building is finished or what. It's happened several times now. I'll try waiting it out next time around.
edit:
Looks like the task was actually canceled simply by doing anything in build mode, like adding/removing a road or some water. Not sure if the rest of the quest line is glitched in the same way as I haven't progressed yet
