NG+ had the famous issue with the enemy hp scaling which made fights last an eternity. Talking about after you reached lvl80 your gear, weapons, powers stranded on the same level but the enemy kept scaling as you leveled up. Also heard some ridiculous bug with the Cardinal almost insta shield respawn so you had to bring a bunch of cobras in order to kill him otherwise you got stuck.
No idea if it got fixed, i didnt see any threads after patch 1.05 (i think?) complaining about it yet so who knows...could be this issue doesnt exist anymore.
Also various others bugs which i believe doesnt exist anymore after the patches - e.g: nomad shield crafting,quest items getting carried over from the previous game...