Re: Mass Effect 2 LE crashing while on the Normandy
One of the modules that interferers with LE1 is "CELib_x64.dll" whitch AFAIK is part of a trainer (Cheat) software.
You should remove this trainer and then repair the game.
(Origin: Game Library > Right-click the game cover > Repair)
(EA app: My Collection > Click on the three dots on the game cover > Repair)
(Steam: Game Library > Right-click the game > Properties > Local Files > Verify integrity of game files.)
Then restart the PC and test.