Re: Origin in game, says it must be turned on? Still not working.

What this guy said... I tried everything from vsync to windowed to windowed full screen to full screen and all sort of permutations I could think of. I remember it had worked one time for me and that was because my MSI Afterburner OSD was screwing up. Sure enough, I closed MSI Afterburner (gives a nice OSD and etc if you aren't sure what this application is) and BOOM! In-game works. There could be multiple solutions that really work, but closing MSI afterburner was the solution that worked for me.

EDIT: Decided to make 100% sure it was MSI afterburner immediately after posting. Re-opened MSI afterburner, immediately loaded DS3 and boom, no in-game. So I can say with 100% certainty that for me, it was definitely MSI afterburner. Close that/FRAPS (maybe even any OSD application you use) and it should work if the other mentioned solutions do not.