@EA_Atic No mods. Only the DLC available in the Origin application. I currently have the console enabled, but this started before I did that. I also have the command line to run using only one core like discussed above. So, tags to the exe, but no mods.
I just had a play session that lasted about an hour, with a few game saves/loads along the way, and a few times I switched windows. I felt like these actions are often potential destabilizers to some applications. They did not seem to matter much, though. The crash happened shortly after an area transition as a plot-important dialog started.
Most of the earlier crashes, if not all, have happened at area transitions, and this is the first I remember that wasn't strictly an area change. (I don't know how it's programmed, but I reckon there are some similar processes at work for the beginnings of these conversations and for loading an area.