Not sure if you figure out any fix but, lowing the graphics settings in certain areas seems to keep the game running. At least in my experience so far with my new Christmas preset. I got a new laptop with a good/decent video card and couldn't play for a couple of weeks until I made some changes. I ended up having to remove the video drivers and re-downloading them from the internet. The game crashed for me when I entered The Deep Roads. After lowering my settings the game ran just fine... I could increase the settings to medium or high for a little while but, would need to save and restart more frequently. Hope this helps.
My gear includes:
Nvidia GeForce GTX 1050 Ti
Windows 10 (compatibility changed to Windows 8)
I normally need to change affinity to a single CPU or else the graphics get a bit weird. Not sure how to explain.
Keep graphics down to low or medium for most of it and change it from time to time.
Hope this helps!