Trouble with my Dragon Age Origins when i have been in denerim for a bit

a new issue i just noticed...

I can open to the intro screen where the bioware screen, but i try to load the saved game and it crashes/closes out (not sure which one to call it maybe both)

on any video setting from low to the highest setting (i tried all settings but it didn't fix the problem

This might be something broken... i don't know if other are having this problem