This happens to me too. I'm in the deep roads where I have to detonate 4 charges and here it keeps crashing to desktop.
Before crashing the controls start acting up...for example when I have to set the primers on the 4 charges, I right click the charge and nothing happens for 30-40 seconds then when I walk away my character assumes the "working" position and the primer appears. Or when It comes to climbing a ladder, I right click it, nothing happens then after 30-40 seconds my character is "teleported" on the ladder and starts climbing.
I'm a bit disapointed that such obvious and easy to reproduce bugs have slipped through QA.
This happens on PC.