I’ve had the game for a couple weeks now and another issue relates to the depth chart: it becomes unresponsive on occasion in franchise mode, where it does not coordinate with what is set on the chart.
For instance, my team’s top three wideouts, RB1 and TE1 can’t enter the field at any point within an on-going game, even though they are first on the chart. Adjusting the chart in-game only changes the order of the players lower in the pecking order. Which basically excludes my best players from the game.
Keep an eye on your rosters in-game.