APPCRASH of MassEffect.exe after Graphics Driver Update - Solution

Those with NVIDIA GPUs who had no luck with starting Mass Effect in compatibility mode or as administrator should try downgrading their PhysX Version to "9.12.0613". You can remove and install it manually.

http://www.nvidia.de/object/physx-9.12.0613-driver-de.html

I hope this problem will be fixed later on.