Mass Effect 3, origin does not work in-game, can't invite friends or view downloadable content in-game.

Same here and for my friends. Trying to invite from within the game gives a "you must have origin in game activated" message. And of course we all have that, since ME 3 came out..

We work around it by tabbing to windows and join game in the friends list from there. Easier if you run the game windowed. But it is only a workaround, please fix it.