Mass Effect 3 stopped working

You have several issues showing up on your DxDiag.

Multiple widowsupdate failure, a Origin client Failure, and NVdisplay.container.exe failure.

Simply put, you have one or multiple issues that can be effecting the game.  Windows update issue needs to be resolved...either by rolling back and redoing the update or seeing if something is blocking an update.  Origin client is a BEX fault, one of the hardest to track down in my opinion, BUT the dll related to it seems to be run time C program AND maybe more important Virtual studios, which MAY be related to the microsoft update failure....so look carefully there.  The last one I mentioned was NVD which is part of the programs from Nvidia company linking your taskbar button to open Geforce experience.  It may all get fixed when you fix other, or you may need to completely clean out Nvidia programs/drivers and do a full reinstall.....

If you want to see what I am talking about, open your DxDiag text and scroll down to the very bottom and look for the listings Fault bucket......

@sunwisecircles

Additional to @mcsupersport, there are several new drivers for your GTX 1060 available here.

Install the graphic driver this way:

• shut down any not necessary programs in the background.
• shout down any and all system monitoring programs and any overlooking tools you might have.

• Download DDU:

• run DDU > save mode >  NVIDIA Software and Drivers > Clean and Restart 

• shut down your virus scanner.

• Run the installation EXE > CUSTOM mode > preform a clean installation > install only the GPU Driver and the PHYSX software.

(don't deselect components you need even if the have the same version number, the installation program will deinstall them if you do)
• Reboot > test

Furthermore go to your Reliability monitor (Press the windows key and "R" at the same time and copy or type "perfmon /rel" (without the quotes) in > ENTER and look if it has ME3 entries.

If yes double click at the last one, copy it to the clipboard, (Bottom left corner) save it to a text file and load it up like the DxDiag.