"Origin Has Stopped Working" during Mass Effect 3 causing freezes

When Origin is running fine in safe mode with networking enabled that means a third party application is blocking it. Below is the copy of our article about Programs that may cause conflicts with Origin for more information:

If you’ve experienced connection issues after updating Origin, you may need to reconfigure your antivirus or firewall settings. Improperly configured settings can result in a situation where Origin is unable to update properly, blocking users from accessing our service.

These conflicts typically manifest in one of two ways:
Difficulty establishing a connection to Origin 
Inability to download, install, or play games 
Difficulty using the Origin Store

Luckily, there are two very simple and common solutions to these problems:

1. Give Origin permission to update. 
Adding Origin to your security program’s “safe” or “allowed” list will usually resolve any connectivity problems that you’re having. Consult your individual program’s software manual, FAQ, or help site for details on how to configure your safe list. 
2. Close background programs before running Origin. 
Disabling your security software can instantly cure connectivity issues, but it can also leave you open to actual threats. If you opt to turn off your antivirus or firewall program, be sure to re-enable it when you’re done using Origin. 
3. Disabling add-ons/extensions/plug-ins before running Origin or accessing the Origin store.
Disabling certain add-ons/extensions/plug-ins that may be interfering with the Origin Store can allow you to continue using the store with less difficulty. You may also wish to try right clicking on the page and selecting "Allow Origin" as this can by-pass some issues. If that doesn't work, you may with to disable them, and re-enable them once finished.

Below is a list of programs that may cause interference with Origin updates. Please note that this is not an exhaustive list. 

Anti-Virus Programs 
Avast! 
AVG Anti-virus 
BitDefender 
Kaspersky Anti-virus 
McAfee Anti-virus 
Nod32 Anti-virus 
Norton/Symantec Anti-virus 
Panda Anti-virus 
Trend Micro 

Anti-Spyware Programs 
Ad Aware 
Spybot Search & Destroy 
Spycatcher Express 
Webroot Spy Sweeper 

Firewall/Security Programs 
Comodo 
McAfee Personal Firewall 
Panda Internet Security 
Zone Alarm 
Online Armor

Add-ons/Extensions/Plug-ins
AdBlock Plus
No-Script

Have you tried in Safe Mode?

If it starts then (and doesn't stop), you can look though your start up programs (msconfig), also, look in add/remove programs as well as your browser's addon's/plugins/extensions...

Google anything you're not sure of as well...

One day I couldn't load anything and while I could load on one of my computers, the other one wouldn't load games... I went to check my plugin's and I saw where Norton had added (without MY knowledge, as software will often do... had added Idenity Safe... I disabled that & problem was solved...

You'll probably have to track it down by ... I'm quite sure all the names/files in my prior post above, aren't the only ones...

Uninstalling AdBlock seems to have resolved all my problems. I can't believe something as simple as a browser extension could cause me so many problems. God I hate Origin. Thanks very much for your help. You adorn that "Hero" rank proudly.