I would just like to add that I too have this very same problem. I recently bought the ME trilogy off GreenManGaming's sale, which included an Origin Key for all three games. I downloaded ME1 and ME2. I was able to find a save file for ME1 to import to ME2, I have played ME2 on Xbox 360 and enjoy that game so I decided to skip ME1 using a save file.
I was able to start the game the first time fine, I had some issues connecting to the Cerberus Network at first but my third attempt at opening the game I connected, no problem.
So I try to import my save file and it gives me the "Run the Configuration Utility" message. So I do that.
That is when the game would no longer run. Just like all of you guys, I hit "Play" and it never loads. I tried many different methods and right now I'm actually downloading the entire game and all DLC again after trying the manual save method, deleting the config.exe and repairing the installation etc.
If this doesn't work, I will not download the entire game again. I have data cap limits, and this is a sizable download. EA will be refunding me my money for all DLC and the game itself if I can't get it to work. It's been over a year, and did anyone truly get their problem fixed by anyone at EA? It seems to me that this issue is still plauging people, this is ridiculous.
