Hey guys,
Sure, sure Spore running on Windows 10, but mostly affected pc's with an Intel Skylake Processor , Asus, Gigabyte.
I myself use it on Windows 10 Pro, it runs without any problems.
I share some more useful links on the subject
This program cannot be executed(8016)". After pressing "Ok" , game quits.
http://answers.ea.com/t5/Crysis-3/When-I-open-Crysis3-it-will-show-quot-This-program-cannot-be/td-p/4696669
Here on the German Game News side "4Players", you'll find patches for manual installation.
http://www.4players.de/4players.php/spieldownloads/Downloads/6851/0/Spore.html
Make sure that the game runs under administrator rights
Good luck