Hi @thelunabell - Here are a few things to try (I know you've done a couple of these already, just added them in case others read this):
- Make sure Origin.exe and SimCity.exe are added to exception lists for your anti-virus, firewall and any other Internet security software like Ad-Block. I know when my anti-virus updates, it occasionally likes to change settings for no good reason.
- Always run install programs "As Administrator"
- Set the desktop icons to run SimCity.exe and Origin.exe "As Administrator"
- If you have the sound program Nahimic 2 from MSI installed, disable or uninstall it.
- If you have any mods installed, remove them
- Make sure your graphics drivers are updated to the most recent version.
- In Origin, right-click SimCity icon, Game Properties, check the box that says "Disable Origin In-game"
- Set the SimCity desktop icon to run in Windows 7 or 8 compatibility mode.
If none of these work, try a clean boot and attempt to launch SimCity. If it launches, you'll have some detective work to do, enable one startup program at a time, reboot, try SimCity, until you find the program that is blocking it. Then you can disable or uninstall the offending program. A clean boot won't stop your anti-virus, so disable that separately.
If you still have issues, reply back with the error message and symptoms. If something works, it would be great to hear about it. Good luck!