Hi @marcmib - Is this a new install of SimCity on your new pc? Just wondering if you have successfully run the game previously and this error message just started appearing, or if you just installed it and are getting this error trying to run it the first time.
Please double-check these settings and try again:
Always run installation files "As Administrator"
Firewall and Antivirus - Make sure SimCity.exe and Origin.exe are added to exception lists. If you have BitDefender installed, disable it.
Graphics drivers and OS are patched and updated to newest versions
SimCity.exe and Origin.exe - Set them to run "as administrator"
Nahimic from MSI - this is an audio management program that comes with MSI motherboards. Disable or uninstall it. Nahimic 2 & 3 are known to cause this issue.
Disable Origin in-game In Origin main menu, right-click SimCity icon, Game Properties, check the box that says "Disable Origin In-game"
Run in Windows 7 or 8 compatibility mode - right-click SimCity shortcut; choose Properties > Compatibility tab > Check the box to run in Win 7 or 8 compatibility mode
Lower your graphics settings - as an older program, SimCity doesn't seem to always work well with 4k settings or dual monitors. If you're running 4k, try reducing the resolution to 1080p first; sometimes changing to single monitor mode will get it running as well
Definitely post back and let us know whether something worked. If it still won't run, reply back with any additional info or error messages you're getting and attach a dxdiag report.
Happy Building!