I believe I have the same issue. Let me just elaborate on what a least my problem is:
I bought the game recently, got around 12 hours played, I've managed to create some huge indistrial cities without problem. I decided to start completely fresh yesterday, deleting all my previous games (again, without problems). However, when I try to play now, the game just closes unexpectedly after no more than five minutes in, returning me to the desktop and a notice telling me that the game has stopped working. (Approximately five minutes in, I experience a FPS spike lasting no more than 1 second, followed by 2 seconds of regular gameplay, before it closes down and brings me back to the desktop.)