Will Simcity 2000 run on windows 10 origin?

The game works on Windows 10 even on 64bit even if you have the disc. the only caveat you will have is that and most maxis games from the early to mid 90s is that they use a 16bit installer which will not work on 64bit versions of windows. just insert the cd then copy all the files from the CD and make a folder then paste all the files their into the folder you made. after install the InstallShield 3 32bit generic installer (by the way it will work for any game that uses a 16bit installer E.G. NFS 2 and Simtown) then extract the installer to the WIN95 Folder then run setup/install32 and follow the steps. but another way is that if your not able to download the 32bit installer or if it doesn't work then you can use Winevdm 

 If you want CD videos to be available go to HKEY_CURRENT_USER\Software\Maxis\SimCity 2000\Paths and change the Goodies key to the drive letter you are using the CD in.

(only do this if you did the first solution)

https://community.pcgamingwiki.com/files/file/111-installshield-3-32-bit-generic-installer/

https://github.com/otya128/winevdm

These are unoffical sites from EA so use them at your risk.