Is there anything that would make you move on from playing TS3?

If they made a game that was 64-bit, had a gorgeous open world and realistic sims, complete with all the standard sims interactions, skills and jobs... then maybe yes. But that's just a pipe dream and in fact they will probably do the reverse and keep releasing closed world games with less detail and more of a cartoony style. I'm happy sticking with TS3 where I can do pretty much anything I want.