Remember, as Mikezumi said, quitting the game without saving is always an option. And meteor strikes without provocation are extremely rare, anyway. I have seen one so far in my game (not counting those in the "bad" version of Oasis Landing), and I assume the use of a telescope outside triggered that one.
I think the most tragic ones are those that hit the school, when pretty much a whole next generation of children and teens gets obliterated. I haven't experienced that myself, but some people have. I don't think I'd save in such a case.
