serious error message

I keep getting a serious error message when trying to play the sims3. anyone else having the same issue? I have done the uninstall and reinstall 4 times and I get the same message serious error has occurred. I have had this issue in the past, but I can't remember how I fixed it before. I think if I remember correctly, it had something to do with one drive. I have un-installed one drive and have had no issues or serious error messages; do we really need one drive or is it not necessary? Because now my sims3 game runs and plays just fi