The only problem I had with the YouTube's Content ID/Copyright system was during my attempts to Let's Plays of Super Mario 64 and Legend of Zelda: Ocarina of Time. Even though I am a huge fan of a certain Nintendo character, the company's policies on Let's Plays, in-game music, and such made me discontinue those Let's Plays. And I do Let's Plays with and without commentary since I prefer that my viewers have that option of talking or no talking. EA doesn't really care as long as the game has been publicly released. Now there may be some issues of Simlish remixes of real life songs, but I've never played Sims 3 and I don't really play much of Sims 4. If I do use in-game music, I will use Sims 1 music since I haven't faced any issues with Jerry Martin's soundtrack.
YouTube: SariaFan93