Only when it comes to pregnancies, infants, or toddlers.
I've ended two pregnancies (via mods) and the first took me months to get over. The second took a couple weeks, and to be honest, I still feel like the worst person in the world for ending them.
I had a male get abducted and pregnant, and I feel so guilty about neglecting a infants, when he gave birth, I kept the little green guy, but soon abandoned the whole save cause it was not how I saw their lives play out.
And I had a story idea about twins being separated at birth, one raised middle class, good manners, loving, tight knit family and the other (as sure you can imagine) neglected and unloved. That never made it past creation cause I could let a toddler be raised that way.
I feel bad about children age, but I can just shake off any of their difficulties as "life happens".
And I'll kill a Sim quick if they anger me. But the kiddos... Yep, I'm guilt-ridden mush.