Hello Try moving your whole mods folder to the desktop. Then start the game and test to see if that helps the issues. If it does help, then put your mods/CC back into the newly generated mods folder in the sims 4 folder one by one or in batches and testing the game after each one to see which is the cause of the problem
Custom careers have been broken by the latest patch so it would be best to remove them and check to see if an updated version of them have been released.