Re: I can't click on my sims or make them interact with other sims
@072913Grace The bottom right of your screen sounds like an outdated version of the UI Cheats Extension mod, which was updated for that issue. You might want to start with the current Broken/Updated Mods list and the previous Broken/Updated Mods list. Be sure to delete old versions before you replace them, and to delete localthumbcache every time you delete or replace a file in the Mods folder.
Many, many outdated mods can cause the other glitches. However, another common cause is mods that aren't installed right. For any script mods you have (.ts4script files are part of the mod), you might want to head to the creator's installation instructions to make sure you've chosen between files you shouldn't have both of and especially that you've installed dependencies -- mods that the mod relies on to make them work right (injector and core mods, mostly), and that those mods are the most recent version.
If both those approaches still aren't working, a 50-50 can narrow the problem down.