Move your Mods folder to the Desktop and delete localthumbcache.package. Then test the game in a new save.
If it works now check for updates to your Mods and CC. Add it back a little at a time while testing until you have found all that are broken.
Hi thanks for your help, I tried that just know but it still says the same thing, what else can I do ?
@oxkimm After you moved your Mods folder to your desktop and deleted the localthumbcache.package file, as @jpkarlsen recommended, did you 1) try repairing your game thru Origin, and 2) try to open the game with a no mod test save?
Don't put any files back into your Mods folder until you can at least launch the game and play normally in a test save. The only file that should be in there for now is the Resource.cfg file.
After your game is working normally again without mods, then you can start testing those.
